Artificial Multivalent Sugar Ligands to Understand and Manipulate Carbohydrate-Protein Interactions
Identifieur interne : 001784 ( Main/Exploration ); précédent : 001783; suivant : 001785Artificial Multivalent Sugar Ligands to Understand and Manipulate Carbohydrate-Protein Interactions
Auteurs : Thisbe K. Lindhorst [Allemagne]Source :
- Topics in Current Chemistry [ 0340-1022 ]
Abstract
Abstract: Multivalency plays an important functional role in carbohydrate-protein interactions. Understanding of the molecular principles underlying multivalency effects is an important goal of biological chemistry. Consequently, a large number of different synthetic mulitvalent glycoligands have been designed to interfere effectively with carbohydrate-protein interactions and to facilitate the investigation of the multiple interactions occurring during these molecular recognition events. Control of inflammation processes and of microbial adhesion are important examples where multivalent carbohydrate ligands might be developed into useful therapeutics such as in the context of an anti-adhesion therapy. Furthermore, cell-cell interactions can also be manipulated by a chemical bioengineering approach which utilizes synthetic substrates in the biosynthetic pathways leading to the assembly of the complex carbohydrate environment on cell surfaces.
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DOI: 10.1007/3-540-45010-6_7
Affiliations:
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